DIV3W

DIV3W is a synthetic fusogenic peptide designed as a delivery platform for nucleic acid therapeutics, particularly small interfering RNAs (siRNAs). It belongs to a class of peptides engineered to overcome major biological barriers to RNA interference, such as poor cellular uptake and endosomal entrapment. DIV3W functions by forming stable, monodisperse nanocomplexes with siRNA, protecting the cargo from enzymatic degradation in physiological environments. Its primary mechanism involves membrane disruption to facilitate endosomal escape, thereby ensuring the bioactive siRNA reaches the cytosol. In preclinical models of ovarian cancer, DIV3W has been used to deliver siRNAs targeting the oncogene CSNK2A1 (Casein Kinase 2 Alpha 1), demonstrating significant mRNA knockdown, inhibition of tumor growth, and reduced metastatic potential. It can also be integrated into tandem systems like LHRHR-DIV3W to provide receptor-mediated targeting to cancer cells overexpressing the luteinizing hormone-releasing hormone receptor.

Other names

fusogenic peptide DIV3W