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divalproex sodium (Abbott Laboratories)
- Development stage
- Approved
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Divalproex sodium is a stable coordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship. It is primarily used as an anticonvulsant for the treatment of epilepsy, a mood stabilizer for bipolar disorder, and for the prophylaxis of migraine headaches. Its mechanism of action is complex and multi-faceted, involving the enhancement of gamma-aminobutyric acid (GABA) neurotransmission through the inhibition of GABA transaminase, blockade of voltage-gated sodium channels, and inhibition of histone deacetylases (HDAC). In the context of neurodegenerative research, divalproex has been investigated for its ability to inhibit glycogen synthase kinase 3 (GSK-3), which may reduce tau protein phosphorylation in Alzheimer's disease, and for its potential to increase brain-derived neurotrophic factor (BDNF) levels in Huntington's disease.
- Brand names
- DepakoteDepakote ERDepakote SprinklesEpival
- Other names
- valproate semisodiumsodium hydrogen divalproate
02
Targets
ABAT (4-aminobutyrate aminotransferase)GSK3 (Glycogen synthase kinase 3 beta)HDAC (HDAC family)NaV (Voltage-gated sodium channels)
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