dixyrazine

Dixyrazine is a typical antipsychotic of the phenothiazine group, structurally classified as a phenothiazine with a piperazine side chain. It acts primarily as an antagonist at dopamine D2 receptor and histamine H1 receptor, giving it both neuroleptic (antipsychotic) and antihistaminic properties[1][7]. Dixyrazine was first introduced in Germany in 1969 and has been used mainly for the management of schizophrenia, other psychoses, anxiety states, agitation, and as an antiemetic[1][4][5]. It also exhibits sedative effects. The drug is administered orally or by intramuscular injection in doses typically ranging from 12.5 to 75 mg per day[1][5]. Its mechanism of action involves antagonism at dopamine D2 receptor (reducing psychotic symptoms) and histamine H1 receptor (contributing to its sedative effect)[7].

Brand names

AnsioleneEsocalmEsucosMetronalRoscal

Other names

dixyrazinedyxirazine