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diyu xiaozhi suppository
- Development stage
- Phase 3
- Lead developer
- Guizhou Liangji Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Rectal
01
Overview
Diyu Xiaozhi suppository is a traditional Chinese medicine (TCM) botanical drug developed for the treatment of internal hemorrhoids. The formulation is primarily based on *Sanguisorba officinalis* (Diyu), a herb recognized in TCM for its ability to cool the blood, stop bleeding, and reduce inflammation. It is specifically indicated for patients with Stage I or II internal hemorrhoids presenting with the damp-heat stagnation pattern. Clinical development, including Phase 3 trials in China (e.g., CTR20130683), has evaluated its efficacy and safety compared to standard treatments like Mayinglong Musk Hemorrhoid Suppository and placebo. The drug is typically administered rectally to provide localized astringent and anti-inflammatory effects.
- Other names
- Compound Sanguisorba suppositoryFufang Diyu Xiaozhi Shuan地榆消痔栓复方地榆消痔栓
02
Targets
15-LOX (Lysyl Oxidase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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