Drug intelligence / Profile preview

diyu xiaozhi suppository

Development stage
Unknown
Lead developer
Guizhou Liangji Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Rectal
01

Overview

Diyu Xiaozhi suppository is a traditional Chinese medicine (TCM) botanical drug developed for the treatment of internal hemorrhoids. The formulation is primarily based on *Sanguisorba officinalis* (Diyu), a herb recognized in TCM for its ability to cool the blood, stop bleeding, and reduce inflammation. It is specifically indicated for patients with Stage I or II internal hemorrhoids presenting with the damp-heat stagnation pattern. Clinical development, including Phase 3 trials in China (e.g., CTR20130683), has evaluated its efficacy and safety compared to standard treatments like Mayinglong Musk Hemorrhoid Suppository and placebo. The drug is typically administered rectally to provide localized astringent and anti-inflammatory effects.

Other names
Compound Sanguisorba suppositoryFufang Diyu Xiaozhi Shuan地榆消痔栓复方地榆消痔栓
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)15-LOX (Lysyl Oxidase)

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