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Drug intelligence / Profile preview
dkk1 multi-epitope vaccine
- Development stage
- Preclinical
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular
01
Overview
A DNA-based vaccine designed to induce immunity against Dickkopf-1 (DKK1), a secreted inhibitor of the canonical Wnt signaling pathway that is upregulated in several bone-related pathologies (especially rheumatoid arthritis and multiple myeloma)[1][2][3][8]. The vaccine utilizes multiple B cell epitope fragments from DKK1, linked together in a synthetic gene construct, and is typically delivered via plasmid DNA for intramuscular immunization. This approach neutralizes DKK1 activity, leading to reduced bone erosion and anti-tumor effects in mouse models. The vaccine stimulates both humoral and cellular immune responses, including the production of neutralizing antibodies against DKK1 and DKK1-specific CD4+ and CD8+ T cells[1][2][3].
- Other names
- dkk1 multiepitope dna vaccinedkk-1 multiepitope dna vaccinedkk 1 multiepitope dna vaccinedickkopf-1 multi-epitope vaccinedickkopf1 multi-epitope vaccinedickkopf 1 multi-epitope vaccine
02
Targets
DKK1 (Dickkopf-related protein 1)MHC I (MHC class I})TLR4 (Toll-like receptor 4)
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