DL76

DL76 is a **histamine H3 receptor antagonist/inverse agonist** with high affinity and selectivity for the H3 receptor, showing excellent in vivo potency in animal models. Its mechanism centers on inhibition of presynaptic H3 autoreceptors, resulting in increased brain histamine release and subsequent protective effects against maximal electroshock (MES)-induced seizures in mice[1][3]. DL76 demonstrates **anticonvulsant activity comparable to valproic acid** and has shown antiparkinsonian effects in preclinical research. DL76 also inhibits the progression of experimental periodontitis in rats by decreasing inflammatory cell infiltration and modulating the RANKL/RANK/OPG pathway, which is involved in bone metabolism[2]. In reproductive and fetal toxicity studies, DL76 showed a low incidence of malformations at tested doses, signifying its therapeutic potential for epilepsy and possibly other neurological or inflammatory diseases[1][3].

Brand names

DL76DL-76DL 76

Other names

DL76DL-76DL 76