Drug intelligence / Profile preview

DMBP

Development stage
Preclinical
Lead developer
Shandong University
Modality
Small Molecules
01

Overview

DMBP: sourced facts only. name: "DMBP induced methuosis and inhibited autophagic flux in cancer cells by inhibiting the function of VPS41, leading to the restrained fusion of late endosomes and autophagosomes with lysosomes." [PMID:36708709]; target: "DMBP induced methuosis and inhibited autophagic flux in cancer cells by inhibiting the function of VPS41, leading to the restrained fusion of late endosomes and autophagosomes with lysosomes." [PMID:36708709]; developer: "Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China." [PMID:36708709]; modality: "a natural small molecule with preferable anticancer activity" [PMID:36708709]; stage: "Moreover, DMBP effectively inhibited metastasis in a mouse metastatic melanoma model." [PMID:36708709]

02

Targets

VPS41 (Vacuolar protein sorting-associated protein 41 subunit of HOPS complex)

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