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DNA GEO-D03
- Development stage
- Phase 1
- Lead developer
- National Institute of Allergy and Infectious Diseases
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular
01
Overview
DNA GEO-D03 is an investigational DNA plasmid vaccine developed by the National Institute of Allergy and Infectious Diseases (NIAID) for the therapeutic treatment of HIV-1 infection. The vaccine is engineered to co-express HIV-1 virus-like particles (VLPs) containing Gag, Pol, and Env antigens, alongside granulocyte-macrophage colony-stimulating factor (GM-CSF), which serves as a molecular adjuvant to enhance immunogenicity. In clinical development, DNA GEO-D03 is typically utilized as a priming agent in a heterologous prime-boost regimen, followed by a boost with the MVA/HIV62B vaccine. This strategy is intended to stimulate robust cellular and humoral immune responses in HIV-1 infected individuals who are virologically suppressed on highly active antiretroviral therapy (HAART).
- Other names
- GEO-D03 DNA vaccineGEO-D-03 DNA vaccineGEO-D 03 DNA vaccine
02
Targets
BCR (Immunoglobulin G B Cell Receptor)CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)HIV-TCR (HIV-specific T-cell receptor)gp41 (Human immunodeficiency virus type 1 glycoprotein 41)Gag (HIV-1 Gag polyprotein)Human immunodeficiency virus type 1 reverse transcriptase
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