dobutamine + norepinephrine

Dobutamine + norepinephrine is a combination of two intravenous cardiovascular agents commonly used together in critical care settings, particularly for the management of shock states such as septic shock or cardiogenic shock. Dobutamine is an inotropic agent that primarily stimulates beta-1 adrenergic receptors, increasing myocardial contractility and cardiac output with relatively mild effects on heart rate and vasodilation. Norepinephrine acts mainly as a potent vasoconstrictor by stimulating alpha-adrenergic receptors, thereby increasing systemic vascular resistance and blood pressure. The combination is used when patients require both increased cardiac output (from dobutamine) and improved vascular tone/blood pressure (from norepinephrine), especially when single-agent therapy is insufficient to achieve hemodynamic goals[1][7][9]. This regimen does not exist as a fixed-dose pharmaceutical product but rather involves co-administration of the two drugs via separate infusions.

Brand names

None known as a fixed-dose combination

Other names

dobutamine and norepinephrinedobutamine plus norepinephrineDOBUTamine and Levophed