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Docetaxel + cisplatin

Development stage
Unknown
Lead developer
Sanofi
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Intravenous
01

Overview

Docetaxel + cisplatin is a combination chemotherapy regimen used primarily for the treatment of non-small cell lung cancer (NSCLC), as well as other cancers such as prostate, head and neck, and gastric cancers. Docetaxel is a taxane antineoplastic agent that binds to microtubules, stabilizing them and preventing their depolymerization, which inhibits mitotic cell division and induces apoptosis in cancer cells[6][8]. Cisplatin is a platinum-based chemotherapeutic that forms DNA crosslinks, leading to DNA damage and apoptosis. The combination exploits complementary mechanisms—docetaxel disrupts microtubule function while cisplatin damages DNA—to enhance cytotoxicity against tumor cells[5][8]. This regimen is approved for first-line therapy in advanced or metastatic NSCLC and has demonstrated efficacy in adjuvant/neoadjuvant settings[1][2][5].

Brand names
Taxotere
Other names
DC regimenCISPDOCE
02

Targets

DNATUBB (Tubulin (alpha and beta subunits))

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