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docetaxel + gemcitabine + carboplatin
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
The combination of docetaxel, gemcitabine, and carboplatin is a multi-agent chemotherapy regimen primarily used in the treatment of advanced non-small cell lung cancer (NSCLC) and has been studied in other solid tumors. Docetaxel is a taxane that stabilizes microtubules, inhibiting cell division. Gemcitabine is a nucleoside analog that inhibits DNA synthesis by incorporating into DNA strands and inhibiting ribonucleotide reductase. Carboplatin is a platinum-based compound that causes DNA crosslinking, leading to apoptosis. Together, these agents act synergistically to disrupt cancer cell proliferation through multiple mechanisms targeting both mitosis and DNA replication[1][4][6][8].
- Other names
- docetaxel and gemcitabine and carboplatin combination chemotherapy
02
Targets
DNATS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))RRM1RRM2CMPK1 (Deoxycytidylate kinase)
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