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docetaxel + fluorouracil + leucovorin
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Docetaxel + fluorouracil + leucovorin is a combination chemotherapy regimen used primarily for the treatment of advanced or metastatic gastric cancer. Docetaxel is a taxane that inhibits microtubule depolymerization, leading to cell cycle arrest and apoptosis. Fluorouracil (5-FU) is an antimetabolite that inhibits thymidylate synthase and interferes with DNA synthesis. Leucovorin enhances the binding of 5-FU to thymidylate synthase, increasing its cytotoxicity. This combination has demonstrated efficacy in patients with advanced gastric cancer and offers an alternative to cisplatin-containing regimens[1][3][5]. The regimen may be administered as infusional or bolus dosing schedules.
- Brand names
- TaxotereAdrucilWellcovorin
- Other names
- docetaxel5-fluorouracilleucovorinLV5FU2 with docetaxelLV-5FU2 with docetaxelLV 5FU2 with docetaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))TS (Thymidylate synthase)
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