docetaxel + thiotepa

Docetaxel + thiotepa is a combination chemotherapy regimen consisting of two cytotoxic agents, docetaxel and thiotepa. Docetaxel is a taxane that promotes and stabilizes microtubule assembly, thereby inhibiting cell division and inducing apoptosis in cancer cells. Thiotepa is an alkylating agent that cross-links DNA strands, preventing DNA replication and leading to cell death. This combination has been used as part of high-dose chemotherapy protocols for the treatment of metastatic breast cancer, often with stem cell rescue[1]. Both drugs are approved for use in various malignancies individually; their combined use aims to enhance antitumor efficacy through complementary mechanisms.