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docetaxel + vinorelbine + filgrastim
- Development stage
- Phase 2
- Lead developer
- Amgen
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
docetaxel + vinorelbine + filgrastim is a combination chemotherapy and supportive care regimen evaluated for the treatment of advanced non-small cell lung cancer (NSCLC). The regimen includes docetaxel, a semi-synthetic taxane that stabilizes microtubules to prevent cell division, and vinorelbine, a vinca alkaloid that inhibits microtubule polymerization. To mitigate the hematological toxicity associated with this dose-dense chemotherapy, filgrastim (a recombinant granulocyte colony-stimulating factor) is administered to stimulate neutrophil production and reduce the risk of febrile neutropenia. This specific combination was studied in a Phase II trial sponsored by Amgen, which provided the filgrastim (Neupogen) component.
- Other names
- docetaxel and vinorelbine with filgrastim support
02
Targets
CSF3R (Granulocyte colony-stimulating factor receptor)TUBB (Tubulin (alpha and beta subunits))
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