Drug intelligence / Profile preview

docetaxel or paclitaxel

Development stage
Unknown
Lead developer
Bristol Myers Squibb
Modality
Small Molecules
Administration
Intravenous
01

Overview

"docetaxel or paclitaxel" is not a single drug but refers to either docetaxel or paclitaxel, both of which are members of the taxane class of chemotherapy agents. These drugs disrupt microtubule dynamics, leading to cell cycle arrest at the G2/M phase and ultimately inducing apoptosis in cancer cells. Both are widely used in the treatment of various cancers, including breast, ovarian, prostate, lung, and gastric cancers. Paclitaxel was originally derived from the bark of the Western Yew tree and is considered a first-generation taxane; docetaxel is a semi-synthetic second-generation derivative. Both drugs can be administered alone or in combination with other chemotherapeutic agents[1][2][3].

02

Targets

TUBB (Tubulin (alpha and beta subunits))

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