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doconexent
- Development stage
- Unknown
- Lead developer
- Ghent University Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Doconexent (docosahexaenoic acid or DHA) is an essential omega-3 polyunsaturated fatty acid that serves as a primary structural component of the human brain, cerebral cortex, skin, and retina. It plays a critical role in neurodevelopment, cognitive function, and the regulation of inflammatory pathways. Doconexent acts as an agonist at free fatty acid receptors, particularly FFAR4 (GPR120) and FFAR1 (GPR40), which mediates its anti-inflammatory and metabolic effects. In clinical development, doconexent-rich supplements have been investigated for their potential to improve fatty acid status, reduce oxidative stress, and modulate inflammatory responses in patients with cystic fibrosis, among other conditions.
- Brand names
- BioDHA
- Other names
- DHAGiving DHA-rich supplementall-cis-docosa-4,7,10,13,16,19-hexaenoic acidcervonic aciddocosahexaenoic acid
02
Targets
FFAR1 (Free fatty acid receptor 1)FFAR4 (Free fatty acid receptor 4)
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