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doconexent ethyl

Development stage: Phase 4
Lead developer: GSK
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration: Oral

Overview

Doconexent ethyl (GSK2212836) is a small molecule drug classified as an omega-3-acid ethyl ester. It is used primarily for the treatment of hypertriglyceridemia and hyperlipidemias. The compound consists mainly of the ethyl ester form of docosahexaenoic acid (DHA), an omega-3 fatty acid. Its mechanism involves reducing triglyceride levels in the blood, likely by decreasing hepatic production of very low-density lipoprotein (VLDL) and increasing triglyceride clearance from plasma. Doconexent ethyl has been developed and marketed in Japan under the synonym TAK-085 for lipid disorders[4].

Other names: omega-3-acid ethyl estersomega3-acid ethyl estersomega 3-acid ethyl estersicosapent ethyl

Targets

RXRA (Retinoid X receptor alpha)

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