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docosahexaenoic acid (Hospital de la Santa Creu i Sant Pau Research Institute)

Development stage: Unknown
Lead developer: Hospital de la Santa Creu i Sant Pau Research Institute
Modality: Small Molecules
Administration: Oral

Overview

Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid being investigated by the Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau for the treatment of metabolic complications in HIV-infected patients. Specifically, it targets hypertriglyceridemia, hypercholesterolemia, and lipodystrophy associated with highly active antiretroviral therapy (HAART). DHA acts as an agonist of the nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma), which promotes adipocyte differentiation and modulates lipid metabolism. It also exhibits anti-inflammatory properties, potentially reducing TNF-alpha levels. In clinical trials, high-dose DHA (4g daily) significantly reduced triglyceride levels in patients on combination antiretroviral therapy.

Brand names: Pro-Mind
Other names: DHAcis-4,7,10,13,16,19-docosahexaenoic acid22:6n-3

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)

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