dodecanedioic acid

Dodecanedioic acid (C-12) is a 12-carbon long-chain dicarboxylic acid that serves as an alternative energy substrate, particularly studied for its potential benefits in metabolic disorders such as type 2 diabetes mellitus and obesity. It is metabolized via $\beta$-oxidation to succinyl-CoA, which enters the citric acid cycle directly. This metabolic pathway is significant because it provides energy to skeletal muscle without stimulating insulin secretion or inhibiting lipolysis, which are common effects of glucose ingestion. By bypassing insulin-mediated glucose uptake, dodecanedioic acid can help maintain muscle glycogen stores and increase fatty acid utilization during physical exercise, potentially reducing muscle fatigue and improving metabolic flexibility in patients with impaired glucose metabolism.

Other names

1,10-decanedicarboxylic acidDDDA