Dolgic Plus

Dolgic Plus is an oral fixed-dose combination analgesic containing the barbiturate butalbital, the non‑opioid analgesic acetaminophen, and the CNS stimulant caffeine, indicated for the relief of the symptom complex of tension (muscle contraction) headaches when alternative non‑opioid therapies are inadequate. Butalbital produces dose‑dependent central nervous system depression by enhancing inhibitory GABAergic neurotransmission, leading to sedation and muscle relaxation that can reduce headache-associated muscle tension. Acetaminophen acts primarily in the central nervous system to inhibit prostaglandin synthesis and modulate pain signaling, providing analgesia and antipyresis without significant peripheral anti‑inflammatory activity. Caffeine, an adenosine receptor antagonist, promotes mild CNS stimulation and cerebral vasoconstriction, and is thought to augment the analgesic efficacy of acetaminophen and counteract barbiturate‑induced drowsiness. Together, these agents provide symptomatic relief of tension headaches but carry risks of dependence, hepatotoxicity from excessive acetaminophen, and additive CNS depression.

Brand names

Dolgic Plus