Drug intelligence / Profile preview

dolutegravir + lamivudine + abacavir + elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide

Development stage
Discontinued
Lead developer
Null
Modality
Small Molecules
Administration
Oral
01

Overview

This is a hypothetical or non-standard combination of seven antiretroviral drugs used in the treatment of HIV infection. The combination includes: - Dolutegravir and elvitegravir, both integrase strand transfer inhibitors (INSTIs) that block the integration of viral DNA into the host genome. - Abacavir, lamivudine, and emtricitabine, which are nucleoside reverse transcriptase inhibitors (NRTIs) that inhibit reverse transcription by causing chain termination during viral DNA synthesis. - Tenofovir alafenamide, a nucleotide reverse transcriptase inhibitor (NtRTI), also inhibiting reverse transcription. - Cobicistat is a pharmacokinetic enhancer (booster) that inhibits cytochrome P450 3A enzymes to increase plasma concentrations of certain antiretrovirals such as elvitegravir. Such a seven-drug regimen does not correspond to any approved fixed-dose combination or standard clinical practice. Each component is approved for HIV treatment but typically used in smaller combinations due to overlapping mechanisms and potential for increased toxicity or drug interactions. This specific multi-drug formulation has not been developed or marketed by any company.

02

Targets

Integrase allosteric pocket (HIV)Human immunodeficiency virus type 1 reverse transcriptaseCYP3A7 (Cytochrome P450 3A7)

Beyond the preview

Go deeper on dolutegravir + lamivudine + abacavir + elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on dolutegravir + lamivudine + abacavir + elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call