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Drug intelligence / Profile preview
domperidone + pantoprazole (Medicraft Group)
- Development stage
- Unknown
- Lead developer
- Medicraft
01
Overview
Antoz DMF is a fixed-dose combination tablet containing the prokinetic agent domperidone (10 mg) and the proton pump inhibitor (PPI) pantoprazole (40 mg). Developed by Medicraft, it is indicated for the treatment of gastrointestinal disorders associated with hyperacidity and impaired motility, such as gastroesophageal reflux disease (GERD), gastritis, dyspepsia, and peptic ulcers. Pantoprazole works by covalently binding to and inhibiting the gastric H+/K+-ATPase pump in parietal cells, thereby reducing stomach acid secretion. Domperidone acts as a selective peripheral dopamine D2 and D3 receptor antagonist, enhancing gastrointestinal motility and accelerating gastric emptying while alleviating symptoms of nausea and vomiting.
- Brand names
- Antoz DMFAntoz DMF Tablet
- Other names
- Pantoprazole 40, Domperidone 10pantoprazole 40 + domperidone 10pantoprazole + domperidone
02
Targets
DRD2 (Dopamine D2 Receptor)ATP4A (Potassium–transporting ATPase alpha chain 1)
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