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donafenib
- Development stage
- Phase 4
- Lead developer
- Suzhou Zelgen Biopharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Donafenib is an orally available small molecule multikinase inhibitor developed for the treatment of various cancers, most notably unresectable hepatocellular carcinoma. It is a deuterated derivative of sorafenib with improved pharmacokinetic properties. Donafenib inhibits multiple kinases, including Raf kinase and several receptor tyrosine kinases such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR). By blocking these targets, donafenib disrupts key signaling pathways involved in tumor cell proliferation and survival. The drug was first approved in China in June 2021 for patients with unresectable hepatocellular carcinoma who have not previously received systemic therapy[1][2][4][7][8].
- Brand names
- ZepsunZeprosenZeprosyn
- Other names
- Sorafenib-d3Sorafenib-d-3Sorafenib-d 3Donafenib tosylate
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)FLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRB (Platelet-derived growth factor receptor beta)RAF1 (c-Raf-1 (Y340D/Y341D))RET (Rearranged during transfection receptor tyrosine kinase)VEGFR1/2/3 (Vascular endothelial growth factor receptor 1 (VEGFR1) / Vascular endothelial growth factor receptor 2 (VEGFR2) / Vascular endothelial growth factor receptor 3 (VEGFR3))FGFR (FGFR family)RTK (Receptor Protein-Tyrosine Kinase)VEGFR (VEGFR family)
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