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donepezil + lithium
- Development stage
- Discontinued
- Lead developer
- Eisai
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of donepezil, an acetylcholinesterase inhibitor, and lithium, a mood stabilizer. This combination has been studied as a potential adjunctive treatment for bipolar disorder, particularly for acute mania. Clinical trials have shown mixed results, with some suggesting short-term benefits but limited long-term efficacy.
02
Targets
AcetylcholinesteraseGSK3 (Glycogen synthase kinase 3 beta)
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