donepezil + scopolamine

Donepezil + scopolamine is a combination of two pharmaceutical agents with opposing actions on the cholinergic system. Donepezil is an acetylcholinesterase inhibitor that increases acetylcholine levels in the brain, primarily used to treat cognitive symptoms of Alzheimer's disease and other dementias by enhancing cholinergic neurotransmission[3][5][6]. Scopolamine, also known as hyoscine, is a muscarinic acetylcholine receptor antagonist that blocks the action of acetylcholine at muscarinic receptors, leading to anticholinergic effects such as sedation and memory impairment. This combination is not used therapeutically due to their antagonistic mechanisms; in fact, co-administration may reduce or negate the benefits of each drug[1]. In research settings, scopolamine is sometimes used to induce temporary cognitive deficits for testing potential cognition-enhancing drugs like donepezil[2][4][8].

Brand names

AriceptTransderm Scop

Other names

E2020 (donepezil)hyoscine (scopolamine)