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donor feces
- Development stage
- Unknown
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Donor feces, also referred to as fecal microbiota transplantation (FMT), is a biological therapeutic intervention consisting of a complex community of gut microbiota (bacteria, fungi, and other microorganisms) derived from healthy donors. Developed and studied by the Academic Medical Center (AMC) in Amsterdam, particularly in the context of the FECAL trial, it is used to treat recurrent *Clostridioides difficile* infection (rCDI). The therapy works by restoring microbial diversity and balance in the recipient's gastrointestinal tract, specifically increasing *Bacteroidetes* species and *Clostridium* clusters IV and XIVa while suppressing the overgrowth of *C. difficile*. It is typically administered via a duodenal or nasoduodenal tube following pre-treatment with vancomycin and bowel lavage.
- Other names
- fecal microbiota transplantationFMTfecal suspensiondonor fecal infusion
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