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donor lymphocyte infusion (Wake Forest University Health Sciences)
- Development stage
- Discontinued
- Lead developer
- Wake Forest University Health Sciences
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Donor lymphocyte infusion (DLI) is an adoptive cell therapy that involves the administration of mature lymphocytes from an allogeneic donor to a transplant recipient. In the specific clinical program led by Wake Forest University Health Sciences, DLI is utilized to accelerate immune reconstitution in patients who have undergone T-cell depleted (CD34+ selected) hematopoietic stem cell transplantation. The infused donor T cells are intended to restore cellular immunity, providing protection against opportunistic infections and mediating a graft-versus-leukemia (GVL) effect to prevent disease relapse. This therapeutic approach is often combined with methotrexate to provide prophylaxis against graft-versus-host disease (GVHD), a common complication of DLI.
- Other names
- DLIdonor lymphocytesInfusion of donor lymphocytes
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