dorsomorphin

Dorsomorphin is a potent, reversible, and ATP-competitive small molecule inhibitor. It was initially identified as an inhibitor of AMP-activated protein kinase (AMPK), but it is also widely recognized for its potent inhibition of Bone Morphogenetic Protein (BMP) type I receptors, including ALK2 (ACVR1), ALK3 (BMPR1A), and ALK6 (BMPR1B). By blocking BMP signaling, dorsomorphin inhibits the phosphorylation of Smad1/5/8. It has been used extensively in research to study metabolic regulation, vascular biology, and embryonic development. While it has shown potential in preclinical models for treating conditions like anemia of chronic disease by suppressing hepcidin expression, it is primarily utilized as a pharmacological tool in vitro and in vivo rather than as a clinical therapeutic.

Other names

6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine