dotarizine

Dotarizine is a pharmaceutical drug classified as a calcium channel blocker, specifically of the cinnarizine family. It acts primarily as an antagonist of voltage-gated calcium channels, with additional antihistaminic and antiserotonergic properties. Dotarizine has been investigated mainly for the prophylactic treatment of migraine and other vascular headaches. Its mechanism involves inhibiting the influx of calcium ions into vascular smooth muscle and neurons, which leads to vasodilation and stabilization of neuronal excitability—key factors in migraine pathophysiology. Dotarizine is not widely approved or marketed globally but has seen clinical use in some countries for migraine prevention.