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double antibiotic paste mixed with chitosan nanoparticles
- Development stage
- Unknown
- Lead developer
- Ain Shams University
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intracanal
01
Overview
Double antibiotic paste mixed with chitosan nanoparticles is an investigational dental medicament developed by Ain Shams University for use in Lesion Sterilization and Tissue Repair (LSTR) therapy. It is specifically designed for the treatment of non-vital primary molars exhibiting pulp necrosis and significant root resorption. The formulation combines two antibiotics (typically ciprofloxacin and metronidazole) with chitosan nanoparticles, which act as a bioactive delivery vehicle. This combination is intended to provide enhanced antimicrobial efficacy against endodontic pathogens and facilitate tissue healing by allowing for a more effective and sustained release of the active ingredients into the root canal system compared to traditional vehicles like propylene glycol.
- Other names
- DAP-CSNPDouble antibiotic paste with chitosan nanoparticles
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