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Double matched sibling hematopoietic stem cell transplantation
- Development stage
- Unknown
- Lead developer
- Beilinson Medical Center
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Double matched sibling hematopoietic stem cell transplantation is an experimental cell therapy protocol developed by the Rabin Medical Center for the treatment of high-risk hematological malignancies. The procedure involves the simultaneous infusion of equal numbers of CD34+ hematopoietic stem cells harvested from two different HLA-matched sibling donors into a single recipient. This approach aims to mimic the enhanced graft-versus-leukemia (GVL) effect observed in double umbilical cord blood transplants, potentially reducing relapse rates in patients with poor-prognosis acute leukemia, multiple myeloma, or advanced lymphoma. The treatment can be administered following either myeloablative or non-myeloablative conditioning regimens and is intended to improve engraftment kinetics and long-term disease-free survival.
- Other names
- Double matched sibling HSCTConcomitant transplantation from 2 matched siblingsHematopoietic stem cell transplantation from two matched sibling donors
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