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Dox-SMDC

Development stage: Preclinical
Modality: Prodrugs/Conditional Activator Small Molecules → Small Molecules

Overview

Dox-SMDC is an experimental **PSMA-targeted small-molecule drug conjugate** designed for targeted treatment of prostate cancer. It consists of a PSMA-binding small molecule derived from the phosphoramidate scaffold CTT1298 linked to **doxorubicin** through a **valine-citrulline dipeptide linker** using click chemistry. The construct binds prostate-specific membrane antigen with high affinity and reportedly irreversible binding, undergoes clathrin-mediated internalization into PSMA-expressing prostate cancer cells, and is intended to selectively deliver the cytotoxic anthracycline payload to tumor cells while reducing nonspecific exposure. Based on the provided literature, Dox-SMDC appears to be a research-stage model conjugate described in preclinical work rather than a commercial or clinically developed drug product.

Other names: PSMA-targeted doxorubicin small-molecule drug conjugate

Targets

PSMA (Prostate-specific membrane antigen)DNA

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