doxifluridine

Doxifluridine is a fluoropyrimidine derivative and an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU). It is converted enzymatically to active 5-FU in the body, where it exerts antitumor activity by inhibiting DNA synthesis in rapidly dividing cancer cells. Doxifluridine has been investigated and used primarily for the treatment of various solid tumors including cancers of the stomach, colon, rectum, breast, uterus, cervix, bladder, and non-small cell lung cancer. Compared to intravenous administration of 5-FU or other oral fluoropyrimidines like tegafur or capecitabine metabolites, doxifluridine offers lower toxicity and improved tolerability due to its oral route[2][3][4][7][10].

Brand names

FurtulonFlutron

Other names

doxifluridineDoxifluridinaDoxifluridinum5'-deoxy-5-fluorouridine5'-DFUR1-(β-D-5-desoxyribofuranoxyl)-5-fluoruracil1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione