doxofylline

Doxofylline is a methylxanthine derivative and bronchodilator used primarily for the treatment of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). It is structurally related to theophylline but has a better safety profile with fewer side effects. The main mechanism of action involves inhibition of phosphodiesterase enzymes (notably PDE3 and PDE4), leading to increased cyclic AMP levels, which causes relaxation of bronchial smooth muscle and bronchodilation. Doxofylline also exhibits anti-inflammatory properties, partly by favoring interleukin-10 release through phosphodiesterase inhibition. Unlike theophylline, it does not significantly inhibit histone deacetylases or act as an antagonist at adenosine receptors except at very high concentrations. Additionally, it interacts with beta-2 adrenoceptors to induce airway smooth muscle relaxation[1][2][6][8].

Brand names

DoxofyllineDoxophylline

Other names

7-(1,3-dioxolan-2-ylmethyl)theophylline