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doxorubicin + cyclophosphamide + cisplatin
- Development stage
- Phase 3
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This combination chemotherapy regimen, consisting of doxorubicin, cyclophosphamide, and cisplatin, is being investigated by West China Hospital in a Phase 2 clinical trial for the treatment of locally advanced or metastatic poorly differentiated or anaplastic thyroid cancer. The study utilizes a precision medicine approach where patient-derived tumor organoids are used for in-vitro drug sensitivity testing to guide the selection of the most effective chemotherapy regimen for individual patients. Doxorubicin is an anthracycline that intercalates into DNA and inhibits topoisomerase II; cyclophosphamide is an alkylating agent that forms DNA cross-links; and cisplatin is a platinum-based antineoplastic agent that creates DNA adducts. Together, these agents aim to inhibit DNA replication and induce apoptosis in aggressive thyroid malignancies.
- Other names
- CAP regimenCIS-DOX-CYC
02
Targets
DNATOP2A (DNA topoisomerase II)
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