Drug intelligence / Profile preview

doxorubicin + bleomycin + dacarbazine + prednisone

Development stage
Preclinical
Lead developer
Farmitalia
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intravenous, Oral
01

Overview

A four-drug combination consisting of **doxorubicin**, **bleomycin**, **dacarbazine**, and **prednisone**. Each component is a well-established antineoplastic or corticosteroid agent. Doxorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II; bleomycin is a glycopeptide that induces DNA strand breaks via free radical formation; dacarbazine is an alkylating agent that methylates DNA; and prednisone is a synthetic glucocorticoid that induces lymphocyte apoptosis and has anti-inflammatory effects. This precise combination as named is not a standard or uniquely branded regimen, but all these drugs are used in combinations for treating Hodgkin lymphoma and other lymphoid malignancies.

02

Targets

TOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)DNA

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