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doxorubicin + bleomycin + vincristine
- Development stage
- Unknown
- Lead developer
- Farmitalia
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A multi-agent chemotherapy regimen combining doxorubicin, bleomycin, and vincristine. Doxorubicin is an anthracycline that intercalates DNA, inhibits topoisomerase II, and generates free radicals, leading to DNA damage and apoptosis. Bleomycin is a glycopeptide antibiotic that binds DNA and induces single- and double-strand breaks via free radical formation, causing cell cycle arrest primarily in G2. Vincristine is a vinca alkaloid that binds β-tubulin and inhibits microtubule polymerization, arresting cells in metaphase. The combination is used in oncology settings where overlapping activity against rapidly dividing cells is desired; historically related regimens appear in lymphomas and solid tumors, though modern standards often prefer other combinations for specific indications.
- Other names
- ABV regimen
02
Targets
DNATOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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