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doxorubicin + ifosfamide + cisplatin
- Development stage
- Unknown
- Lead developer
- Farmitalia
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of doxorubicin (an anthracycline antibiotic), ifosfamide (an alkylating agent), and cisplatin (a platinum-based compound). This regimen is primarily used in the treatment of sarcomas, particularly osteosarcoma, and has also been studied in soft tissue sarcomas, nasopharyngeal carcinoma, and uterine leiomyosarcomas. The combination works through multiple mechanisms including DNA intercalation, topoisomerase II inhibition, DNA cross-linking, and formation of DNA adducts.
- Other names
- APIDIA
02
Targets
TOP2A (DNA topoisomerase II)DNA
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