Drug intelligence / Profile preview

doxorubicin-MagSiNs

Development stage
Preclinical
Lead developer
Florida International University
Modality
Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Parenteral
01

Overview

**doxorubicin-MagSiNs** is an experimental, magnetically activated nanoparticle formulation that carries the anthracycline chemotherapy drug doxorubicin. Its MagSiN carrier comprises a magnetostrictive cobalt ferrite core enclosed by a piezoelectric fused-silica shell containing doxorubicin. An external low-strength magnetic field is intended to promote cancer-cell nanoporation and on-demand payload release, enabling localized doxorubicin cytotoxicity while limiting exposure of normal endothelial cells. The platform has been evaluated in vitro in metastatic triple-negative breast cancer, ovarian cancer, and prostate cancer cell models; it is not an approved medicine or a registered clinical-stage product. ([mdpi.com](https://www.mdpi.com/1424-8247/15/10/1216))

Other names
Dox-MagSiNsdoxorubicin-MagSiNs
02

Targets

TOP2A (DNA topoisomerase II)DNA

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