Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
doxycycline (Universidade Estadual de Campinas)
- Development stage
- Unknown
- Lead developer
- Universidade Estadual de Campinas
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Doxycycline (20%) encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres is an investigational local drug delivery system developed by the University of Campinas for the treatment of chronic periodontitis. Doxycycline is a broad-spectrum tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. In this specific formulation, the antibiotic is loaded into biodegradable PLGA microspheres for subgingival delivery, providing sustained release as an adjunct to ultrasonic periodontal debridement. This approach targets periodontal pathogens such as *Porphyromonas gingivalis* and *Fusobacterium nucleatum* directly within the periodontal pocket to reduce inflammation and pocket depth.
- Brand names
- ActiclateAdoxaAdoxa CKAdoxa PakAdoxa TTAlodoxDoryxDoryx MPCMonodoxOraceaPeriostatVibramycin CalciumVibramycin HyclateVibra-TabsApprilon (Canada)Atridox (US)Doxycin (India)Lymepak (US)Mondoxyne NL (US)Morgidox (US)Okebo (Japan)Targadox
- Other names
- doxiciclinedoxycycline 20% PLGA microsphereslocally delivered doxycycline
02
Targets
30S secondary site (Bacterial 30S ribosomal subunit secondary RNA site)MMP12 (Macrophage Metalloelastase)Mitoribosome (Mitochondrial ribosome)Bacterial Ribosome
Beyond the preview
Go deeper on doxycycline (Universidade Estadual de Campinas).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on doxycycline (Universidade Estadual de Campinas).