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DP-9024
- Development stage
- Preclinical
- Lead developer
- Deciphera Pharmaceuticals
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
DP-9024 is an investigational bispecific antibody developed by D&P Bio-tX, designed to simultaneously target CD47 and Programmed Death-Ligand 1 (PD-L1). By blocking the "don't eat me" signal mediated by CD47 on tumor cells and the PD-1/PD-L1 checkpoint pathway, DP-9024 aims to synergistically activate both the innate and adaptive immune systems. The dual-targeting approach is intended to improve therapeutic efficacy while potentially reducing the off-target toxicities, such as hemagglutination, often associated with monotherapy CD47 inhibitors. It is primarily being developed for the treatment of various solid tumors using the company's proprietary de novo protein design platform.
- Other names
- CD47/PD-L1 bispecific antibody
02
Targets
EIF2AK4 (Eukaryotic translation initiation factor 2-alpha kinase 4)EIF2AK3 (Pkr-like endoplasmic reticulum kinase)CD47 (Cluster of Differentiation 47)CD274 (Programmed cell death protein 1 ligand 1)
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