Drug intelligence / Profile preview

DP1038

Development stage
Phase 1
Lead developer
Dauntless Pharmaceuticals
Modality
Cyclic Peptides → Modified Peptides → Peptides, Small Molecules, Recombinant Proteins and Enzymes
Administration
Intranasal
01

Overview

DP1038 is a novel intranasal formulation of octreotide acetate developed by Dauntless Pharmaceuticals. It is designed as a non-invasive alternative to injectable somatostatin analogs for the treatment of acromegaly and neuroendocrine tumors. Octreotide is a synthetic peptide analog of somatostatin that inhibits the secretion of growth hormone (GH) from pituitary adenomas and other hormones from neuroendocrine tumors. The mechanism involves agonism at somatostatin receptors, leading to suppression of GH and insulin-like growth factor 1 (IGF-1) levels. DP1038 leverages patented absorption technology from Aegis Therapeutics to enhance nasal bioavailability, aiming to provide efficacy comparable to subcutaneous injections with improved patient convenience and tolerability[2][3][4][5][7].

Other names
intranasal octreotideoctreotide acetate intranasal formulation
02

Targets

SSTR1 (Somatostatin Receptor Type 1)SSTR2 (Somatostatin receptor type 2)SSTR3 (Somatostatin receptor 3)SSTR4 (Somatostatin receptor 4)SSTR5 (Somatostatin receptor 5)GHRHR (Growth hormone-releasing hormone receptor)SSTR (Somatostatin receptors)

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