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dpa-714 (Bayer)
- Development stage
- Preclinical
- Lead developer
- Bayer
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
DPA-714 is a small molecule ligand that specifically binds to the translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor. It is commonly radiolabeled with fluorine F 18 to create a PET imaging agent (fluorine F 18-DPA-714 or [18F]DPA-714) for detecting TSPO-expressing cells in vivo. TSPO is upregulated in various pathological conditions, particularly neuroinflammation and activated macrophages. DPA-714 has high affinity for TSPO and stimulates pregnenolone synthesis. The compound has been used primarily as a biomarker for neuroinflammation and in research settings to image inflammation associated with diseases such as Alzheimer's disease, epilepsy, rheumatoid arthritis, and brain tumors using positron emission tomography (PET)[1][3][4][5][6][7].
- Other names
- fluorine F 18-DPA-714
02
Targets
TSPO (Translocator Protein (18 kDa))
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