dpdpe

DPDPE is a synthetic cyclic peptide and a highly selective agonist of the delta-opioid receptor (DOR). It was developed in the early 1980s as the first highly selective DOR agonist and is derived from structural modification of met-enkephalin. The molecule contains D-penicillaminyl residues at positions 2 and 5 that form a disulfide bridge, conferring rigidity and selectivity. DPDPE is primarily used in scientific research to study opioid receptor pharmacology and pain mechanisms. It exhibits potent antinociceptive effects *in vivo* when administered intracerebroventricularly but has limited activity after peripheral administration due to poor blood-brain barrier permeability. Its mechanism of action involves full agonism at the delta-opioid receptor[1][3][4][5].

Other names

L-Tyrosyl-D-penicillamyl-glycyl-L-phenylalanyl-D-penicillamine (2->5)-disulfideH-Tyr-D-Pen(1)-Gly-Phe-D-Pen(1)-OH