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DPP3-MSN

Development stage: Preclinical
Lead developer: Vrije University Medical Center
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules

Overview

**DPP3-MSN** is an experimental, DPP3-responsive mesoporous silica nanoparticle drug-delivery system developed for targeted treatment of pancreatic ductal adenocarcinoma. In the reported preclinical work, the nanoparticle was loaded with paclitaxel and incorporated a peptide linker designed to be cleaved by intracellular dipeptidyl peptidase 3, which is enriched in pancreatic ductal adenocarcinoma cells. Paclitaxel-loaded DPP3-MSN showed pancreatic ductal adenocarcinoma selectivity in vitro and reduced leukopenia without observed organ damage in mouse studies; antitumor efficacy findings emphasized CAPN2-MSN rather than DPP3-MSN. ([scholarlypublications.universiteitleiden.nl](https://scholarlypublications.universiteitleiden.nl/access/item%3A3970609/view))

Other names: DPP3-responsive mesoporous silica nanoparticleDPP-3-responsive mesoporous silica nanoparticleDPP 3-responsive mesoporous silica nanoparticleDPP3-responsive MSNDPP-3-responsive MSNDPP 3-responsive MSN

Targets

TUBB (Tubulin (alpha and beta subunits))DPP3 (Dipeptidyl peptidase 3)

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