Drug intelligence / Profile preview

DPV-007

Development stage
Preclinical
Lead developer
UbiVac
Modality
Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
Administration
Intralymphatic
01

Overview

**DPV-007** is an investigational dendritic cell-targeted microvesicle therapeutic cancer vaccine developed by UbiVac to intercept progression of high-grade oral dysplasia to oral cancer. The vaccine is manufactured using the DRibble platform and contains a broad, non-individually prescribed mixture of tumor-associated proteins, short-lived and non-canonical proteins, damage-associated molecular patterns, and molecular chaperones packaged in microvesicles. DPV-007 contains proteins associated with oral dysplasia and oral cancer and has reported agonist activity at Toll-like receptors 2, 3, and 9, supporting innate immune activation and subsequent tumor-antigen-specific adaptive immune responses.

02

Targets

TLR9 (Toll-like receptor 9)TLR3 (Toll-like receptor 3)TLR2 (Toll-like Receptor 2)

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