Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
DQ-Lipo
- Development stage
- Preclinical
- Lead developer
- Sun Yat-sen University
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
DQ-Lipo is a liposomal formulation of DQ, a carbamodithioic acid derivative designed as a reactive oxygen species (ROS)-responsive prodrug. Developed primarily for the treatment of ARID1A-mutant ovarian clear cell cancer (OCCC), DQ-Lipo exploits the high basal ROS and low glutathione (GSH) levels characteristic of these tumor cells. Upon exposure to ROS, DQ undergoes a transformation to release dithiocarbamate (DDC) and quinone methide (QM). QM targets and depletes GSH, while DDC chelates intracellular or co-administered copper (Cu) to form Cu(DDC)2, a potent cytotoxic agent. This cascade results in a massive increase in ROS, disruption of redox homeostasis, inhibition of the epithelial-mesenchymal transition (EMT), and induction of immunogenic cell death (ICD), thereby suppressing tumor growth and metastasis.
- Other names
- Liposomal DQ
Beyond the preview
Go deeper on DQ-Lipo.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DQ-Lipo.