DR-2001b

DR-2001b is a specific dosage or formulation of DR-2001, an investigational vaginal ring containing the synthetic steroid danazol. Developed by Duramed Research (a subsidiary of Barr Pharmaceuticals, now part of Teva), it was designed for the localized treatment of moderate to severe endometriosis-related nonmenstrual pelvic pain. Danazol acts as a pituitary-ovarian axis suppressor by inhibiting the mid-cycle surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It also exerts direct effects by binding to androgen, progesterone, and glucocorticoid receptors, and by inhibiting enzymes involved in steroidogenesis. The vaginal ring delivery system was intended to provide sustained, local release of the drug to the pelvic tissues, potentially achieving therapeutic efficacy with lower systemic exposure and fewer androgenic side effects (such as weight gain and acne) compared to oral danazol administration.

Other names

Danazol Vaginal Ring