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Draksha Guduchyadi Kashaya is a traditional Ayurvedic decoction (kashaya) and mouthwash utilized primarily for alleviating oral complications such as oral mucositis, xerostomia, pharyngitis, laryngitis, ulcers, and pain associated with chemo-radiation in head and neck cancers, as well as for stomatitis and other oral diseases[2][3][4][6]. Its formulation contains ingredients like Draksha (grape), Guduchi (Tinospora cordifolia), Daruharidra (Berberis aristata), and Pippali (Piper longum), among others, known for their anti-inflammatory, immunomodulatory, detoxifying, and wound-healing properties[1][2]. The mechanism of action is centered on reducing inflammation, promoting wound healing, oral decontamination, immune regulation, and balancing doshas (tridosha shamana) through astringent (kashaya), bitter (tiktha), sweet (madhura) tastes and cold potency (sita virya) as per Ayurveda[2][3][5]. It is administered as a mouthwash (kavala) and occasionally as a decoction or capsule for broader use in digestive, hepatic, skin, and joint disorders[1][4][6]. It is recommended within integrative oncology protocols and general Ayurvedic management of mucositis, stomatitis, and other oral pathologies.
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