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dronabinol + clonidine
- Development stage
- Unknown
- Lead developer
- McLean Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Dronabinol + clonidine is a combination therapy being investigated by McLean Hospital for the treatment of cannabis dependence, particularly in patients with comorbid schizophrenia or schizoaffective disorder. Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (THC) that acts as a partial agonist at the cannabinoid CB1 and CB2 receptors, serving as a replacement therapy to mitigate withdrawal symptoms. Clonidine is an alpha-2 adrenergic agonist that helps alleviate the autonomic symptoms of withdrawal, such as anxiety and restlessness. This combination approach aims to improve treatment retention and reduce cannabis use in a population where substance use disorders significantly worsen clinical outcomes.
- Other names
- Dronabinol and Clonidine combinationDronabinol/Clonidine
02
Targets
CNR1 (Cannabinoid receptor 1)ADRA2A (α2A)
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